We are a group of researchers working at the interface of chemistry and biology to understand the fundamentals of biomolecular interactions. Using simple chemical methods our aim is to develop molecular tools based on DNA aptamers, which eventually will have applications in biochemistry, cell biology, and biomedical research. Our laboratory is focused on two major areas:
- Investigation of novel SELEX technologies to select aptamers against biologically important cellular targets.
- Design and synthesis of novel multivalent, multifunctional aptamer scaffolds for biomedical applications. We are also interested in structure-activity relationship studies of monomeric and multimeric aptamers.