Sana Batool, Sanam Bhandari, Shanell George, Precious Okeoma, Nabeela Van, Hazan E. Zümrüt, and Prabodhika Mallikaratchy “Engineered Aptamers to Probe Molecular Interactions on the Cell Surface” Biomedicines. 2017 Aug 29;5(3). pii: E54. doi: 10.3390/biomedicines5030054.

Hazan E. Zümrüt, Sana Batool, Nabeela Van, Shanell George, Sanam Bhandari, George E. Maio and Prabodhika   Mallikaratchy*. Structural optimization of an aptamer generated from Ligand guided Selection (LIGS) resulted in high affinity variant toward mIgM expressed on Burkitt’s lymphoma cell lines: Biochim Biophys Acta. 2017 Mar 28. pii: S0304-4165(17)30111-3. doi: 10.1016/j.bbagen.2017.03.020. Read this article.

GE Maio, O Enweronye, HE Zumrut, S Batool, NA Van, PR MallikaratchyChemistrySelect 2 (7),  2335-2340, “Modification of 2’-OMe RNA analogues enhances the stability of an aptamer evolved against Myeloid Leukemia cells” :ChemistrySelect. 2017: 2 (7), 2335-2340 Read this article. Google Scholar

Mallikaratchy, P. “Evolution of Complex Target SELEX to Identify Aptamers against Mammalian Cell-Surface Antigens” Molecules. Jan 30;22(2). pii: E215. doi: 10.3390/molecules22020215. Read this article.

Hasan Zümrüt, Naznin Ara, George Maio, Nabeela Van, Sana Battol and Prabodhika Mallikaratchy “Ligand-guided selection of aptamers against T-cell Receptor-cluster of differentiation 3 (TCR-CD3) expressed on Jurkat.E6 cells”. Anal Biochem. 2016 Aug 9;512:1-7 doi: 10.1016/j.ab.2016.08.007. Read this article.

Hasan Zümrüt, Naznin Ara, Maria Fraile, George Maio, Prabodhika Mallikaratchy “Ligand-Guided Selection of Target-Specific Aptamers: A Screening Technology for Identifying Specific Aptamers Against Cell-Surface Proteins”. Nucleic Acid Ther. 2016 Jun;26(3):190-8. doi: 10.1089/nat.2016.0611. Epub 2016 May 5. Read this article. Read the editorial on this article.


Prabodhika Mallikaratchy, Zumrut, Hasan, Ara, Naznin “Discovery of Biomarkers Using Aptamers Evolved in Cell-SELEX Method”, Aptamers selected by cell-SELEX for Theranostics” Principles, Eds. W. Tan and X. Fan, SpringerLink. 2015; p.265. Read this ebook.

Prabodhika R. Mallikaratchy, Jeffrey R. Gardner, Lars Ulrik R. Nordstrøm, Nickolas J. Veomett, Michael R. McDevitt, Mark L. Heaney and David A. Scheinberg. “A self-assembling short oligonucleotide duplex for use in vivo” Nucleic Acids Therapeutics, Volume: 23 Issue 4: July 31, 2013. Read this article. pubmed

US Patent: 13/510,221, Mallikaratchy, Prabodhika, and Scheinberg David, COMPOSITIONS AND METHODS FOR TREATING CANCER AND OTHER DISEASES

Prabodhika R. Mallikaratchy, Alessandro Ruggiero, Jeffrey R. Gardner, Vitaly Kuryavyi, William F. Maguire, Mark L. Heaney, Michael R. McDevitt, Dinshaw J. Patel and David A. Scheinberg. “A multivalent DNA aptamer specific for the B cell receptor on human lymphoma and leukemia” Nucleic Acids Res. . 2011; 39(6): 2458. Read this article. pubmed

Tang Z., Zhu Z., Mallikaratchy P., Yang R., Sefah K., Tan W. “Aptamer-target binding triggered molecular mediation of singlet oxygen generation” Chem. Asian J. 2010; 5 (4): 783. Read this article. pubmed

Mallikaratchy P., Liu H., Huang Y.-F., Wang H., Lopez-Colon D. and Tan W. “Using aptamers evolved from cell-SELEX to engineer a drug delivery platform” Chem. Commun. 2009; 7 (21): 3056. Read this article. pubmed

Mallikaratchy P. and Tang Z., Tan W. “Aptamers evolved from whole cell selection as a selective anti-tumor photodynamic agent”ChemMedChem. 2008; 3 (3): 425. Read this article.

Tang Z., Mallikaratchy P., Yang R., Kim Y., Zhu Z., Wang H. and Tan W. “Aptamer switch probe based on intramolecular displacement” J. Am. Chem. Soc. 2008; 130 (34): 11268. Read this article. pubmed

Shangguan D., Meng L., Mallikaratchy P., Li Y. and Tan, W.  “Cell-specific aptamer probes directing cancer biomarker discovery in cancer cells” J. Proteomic Res. 2008; 7 (5): 2133. Read this article.

Mallikaratchy P., Tang Z., Kwame S., Meng L., Shangguan D., and Tan W. “Aptamer directly evolved from live cells recognize membrane bound immunoglobin heavy mu chain on Burkitt’s lymphoma cells” Mol. Cell. Proteomics. 2007; 6 (12): 2230. Read this article. pubmed

Mallikaratchy P., Chen H., Tang Z., Meng L., Shangguan D., Parekh P., Kim Y., Sefah, K., and Tan W. “DNA aptamers for molecular imaging and profiling of cancer”, American Pharm. Rev. 2007; 10 (6): 134.

Tang Z., Shangguan D., Wang K., Kwame S., Mallikaratchy P., Li, Y., and Tan, W. “Selection of aptamers for molecular recognition and characterization of cancer cells” Anal. Chem. 2007; 79 (13): 4900. Read this article. pubmed

Shangguan, D., Tang, Z., Mallikaratchy P., Xiao Z., Tan W. “Optimizations and modifications of aptamers selected from live cancer cells”ChemBioChem. 2007; 8 (6): 603. Read this article. pubmed

H. Chen, Y. Kim, M. O’Donoghue, P. Mallikaratchy, J. Martin, Z. Tang, D. Shangguan, and W. Tan, “Fluorescent Aptamer Probes”, Functional Nucleic Acid Sensors Based on Different Transduction Principles, Eds. Yi Lu and Yingfu Li, SpringerLink. 2007; p.111. Read this article. Google Scholar

Shangguan D., Li Y., Tang Z., Cao Z., Chen H., Mallikaratchy P., Kwame S., Yang C. J., and Tan W. “Aptamers evolved from live cells as effective molecular probes for cancer study” Proc. of Natl. Acad. of Sci USA. 2006; 103: 11838. Read this article. pubmed

Mallikaratchy P., Stahelin R., Cao Z., Cho W., and Tan W. “Combinatorial selection and binding of high affinity DNA ligands targeting protein kinase C delta” Chem. Comm.  2006; 30: 3229. Read this article. pubmed

W. Tan, Z. Cao, D. Shangguan, Y. Li, Z. Tang, P. Mallikaratchy and H. Chen. “Cancer cell proteomics using molecular aptamers”, Drug Discovery Handbook, Ed. Shayne Cox Gad, Wiley-Inter science, 2005; p. 73. Read this article. Google Scholar

Mallikarachy P., Fronczek F. R., Brotherton H. O., and Junk T. “Facile Access to novel organotellurium heterocycles by nitration of Bis- (3, 5-Dimethylphenyl) Ditelluride” J. Het. Chem. 2005; 42 (2): 243. Read this article. Google Scholar

Mallikaratchy P., Norman R. E., Fronczek F. R., and Junk T. “Diazenediyldiphenyl-2C2′, N1)-bis [(3,5-dimethyl-phenyl) tellurium(II)]” Acta. Crystallographica. 2005; E61 (7): m1370. Read this article. Google Scholar

Mallikaratchy P., Norman R. E., Fronczek F. R., and Junk T. “Tribromo(3,5-dimethyl-2-nitrophenyl-κ2C1,O)tellurium(IV),-bromo(3,5-dimethyl-2-nitrophenyl-κ2C1,O)-tellurium-(II) and bromo(3,5-dimethyl-nitroso-phenyl- κ2  C1,O) tellurium(II)” Acta Crystallographica. 2003; C59: o571. Read this article. pubmed