Conformational behaviour and molecularity of novel anti-IgM G-quadruplex forming aptamers

Federica Moccia, Domenica Musumeci, Chiara Platella, John Bradshaw, Prabodhika Mallikaratchy, Daniela Montesarchio. “Conformational behaviour and molecularity of novel anti-IgM G-quadruplex forming aptamers” 2018 August 19; 256th ACS National Meeting

Ligand-guided selection (LIGS): A SELEX variant to identify specific aptamers against cell-surface markers

Hasan Zumrut, Sana Batool, Kimon Argyropoulos, Rigzin Dekhang, Prabodhika Mallikaratchy. “Ligand-guided selection (LIGS): A SELEX variant to identify specific aptamers against cell-surface markers” 2018 August 19. 256th ACS National Meeting.

Design of a dimeric aptamer against B-cell receptor

Sana Batool, Hasan Ekrem Zumrut, Sanam Bhandari, Nabeela Van, Shanell George, Prabodhika Mallikaratchy. “Design of a dimeric aptamer against B-cell receptor” 2018 March 18. 255th ACS National Meeting.

Engineered Aptamers to Probe Molecular Interactions on the Cell Surface

Sana Batool, Sanam Bhandari, Shanell George, Precious Okeoma, Nabeela Van, Hazan E. Zümrüt, and Prabodhika Mallikaratchy “Engineered Aptamers to Probe Molecular Interactions on the Cell Surface” Biomedicines. 2017 Aug 29;5(3). pii: E54. doi:10.3390/biomedicines5030054.

Structural optimization of an aptamer generated from Ligand guided Selection (LIGS) resulted in high affinity variant toward mIgM expressed on Burkitt’s lymphoma cell lines: Biochimica et Biophysica Acta (BBA)-General Subjects

Hazan E. Zümrüt, Sana Batool, Nabeela Van, Shanell George, Sanam Bhandari and Prabodhika Mallikaratchy Structural optimization of an aptamer generated from Ligand guided Selection (LIGS) resulted in high affinity variant toward mIgM expressed on Burkitt’s lymphoma cell lines: Biochimica et Biophysica Acta (BBA)-General Subjects.2017 July 01; 1861(7):1825-1832. pii: S0304-4165(17)30111-3. doi:10.1016/j.bbagen.2017.03.020.

Optimization of structure of an aptamer discovered utilizing Ligand Guided Selection (LIGS) yields high affinity aptamer

Hasan Ekrem Zumrut, Sana Batool, Nabeela Van, Prabodhika Mallikaratchy. “Optimization of structure of an aptamer discovered utilizing Ligand Guided Selection (LIGS) yields high affinity aptamer” 2017 April 2. 253rd ACS National Meeting.

Compositions and methods for treating cancer and other disease

US Patent Application: 14/727,509 David A Scheinberg, Prabodhika Mallikaratchy, Compositions and methods for treating cancer and other disease

Systematic Optimization and Modification of a DNA Aptamer with 2’-O- Methyl RNA Analogues

George E Maio, Osita Enweronye, Hasan E Zumrut, Sana Batool, Nabeela A Van, Prabodhika R Mallikaratchy “Systematic Optimization and Modification of a DNA Aptamer with 2’-O- Methyl RNA Analogues” 2017 March 01; ChemistrySelect 2(7), 2335-2340.

Modification of 2’-OMe RNA analogues enhances the stability of an aptamer evolved against Myeloid Leukemia cells

Mallikaratchy, P. “Evolution of Complex Target SELEX to Identify Aptamers against Mammalian Cell-Surface Antigens” Molecules. Jan 30;22(2). pii: E215. doi:10.3390/molecules22020215.

Ligand-guided selection of aptamers against T-cell Receptor-cluster of differentiation 3 (TCR-CD3) expressed on Jurkat.E6 cells

Hasan Zümrüt, Naznin Ara, George Maio, Nabeela Van, Sana Battol and Prabodhika Mallikaratchy “Ligand-guided selection of aptamers against T-cell Receptor-cluster of differentiation 3 (TCR-CD3) expressed on Jurkat.E6 cells”. Anal Biochem. 2016 November 01;512:1-7 doi: 10.1016/j.ab.2016.08.007.