Homodimeric variant of an aptamer generated from LIGS activates TCR-CD3ε Complex
Freage, L., Jamal, D., and Mallikaratchy, P. “Homodimeric variant of an aptamer generated from LIGS activates TCR-CD3ε Complex”: bioRxiv 2020.05.18.102145.
Ligand Guided Selection (LIGS) with Artificially Expanded Genetic Information Systems against TCR-CD3ε
Zumrut, H.; Yang, Z.; Williams, N.; Arizala, J. D. R.; Batool, S.; Benner, S.; Mallikaratchy, P. R. *”Ligand Guided Selection (LIGS) with Artificially Expanded Genetic Information Systems against TCR-CD3ε”; Biochemistry; 2020 Jan 8. doi: 10.1021/acs.biochem.9b00919.
Discovery of artificial nucleic acid ligands against cell surface targets
Zumrut, H.; Mallikaratchy, P.R.*; “Discovery of artificial nucleic acid ligands against cell surface targets”, ACS Appl. Bio Mater. 2019; in press;
Integrating Ligand-Receptor Interactions and In Vitro Evolution for Streamlined Discovery of Artificial Nucleic Acid Ligands
Hasan Zumrut, Sana Batool, Kimon Argyropoulos, Nicole Williams, Roksana Azard, and Prabodhika Mallikaratchy* “Integrating Ligand-receptor Interactions and In Vitro Evolution for Streamlined Discovery of Artificial Nucleic Acid Ligands” Mol Ther Nucleic Acids. 2019 Sep 6;17:150-163. doi: 10.1016/j.omtn.2019.05.015. Epub 2019 Jun 4.
The role of G-quadruplex structures of LIGS-generated aptamers R1. 2 and R1. 3 in IgM specific recognition
Federica Moccia,Chiara Platella, Domenica Musumeci, Sana Batool, , Hasan Zumrut, John Bradshaw, Prabodhika Mallikaratchy*, Daniela Montesarchio* “The role of G-quadruplex structures of LIGS-generated aptamers R1. 2 and R1. 3 in IgM specific recognition” : Int J Biol Macromol. 2019 Apr 22; 133:839-849. doi:10.1016/j.ijbiomac.2019.04.141; 2019.
Ligand-guided-selection method for screening antigen-specific ligands
US Patent application: 10/253,314, “Ligand-guided-selection method for screening antigen-specific ligands”
Synthesis of stable azide and alkyne functionalized phosphoramidite nucleosides
S Lingala, LU Nordstrøm, PR Mallikaratchy “Synthesis of stable azide and alkyne functionalized phosphoramidite nucleosides”: Tetrahedron Letters, 2019 January 17; 60(3):211-213. doi:10.1016/j.tetlet.2018.12.018
Dimerization of an aptamer generated from Ligand-guided selection (LIGS) yields a high affinity scaffold against B-cells
Sana Batool, Kimon V Argyropoulos, Roksana Azad, Precious Okeoma, Hasan Zumrut, Sanam Bhandari, Rigzin Dekhang, Prabodhika Mallikaratchy* ” Dimerization of an aptamer generated from Ligand-guided selection (LIGS) yields a high affinity scaffold against B-cells “Biochimica et Biophysica Acta (BBA)-General Subjects 1863 (1), 232-240. doi:10.1016/j.bbagen.2018.10.006. Epub 2018 Oct 17.
Conformational behaviour and molecularity of novel anti-IgM G-quadruplex forming aptamers
Federica Moccia, Domenica Musumeci, Chiara Platella, John Bradshaw, Prabodhika Mallikaratchy, Daniela Montesarchio. “Conformational behaviour and molecularity of novel anti-IgM G-quadruplex forming aptamers” 2018 August 19; 256th ACS National Meeting
Ligand-guided selection (LIGS): A SELEX variant to identify specific aptamers against cell-surface markers
Hasan Zumrut, Sana Batool, Kimon Argyropoulos, Rigzin Dekhang, Prabodhika Mallikaratchy. “Ligand-guided selection (LIGS): A SELEX variant to identify specific aptamers against cell-surface markers” 2018 August 19. 256th ACS National Meeting.