Integrating Ligand-Receptor Interactions and In Vitro Evolution for Streamlined Discovery of Artificial Nucleic Acid Ligands

Hasan Zumrut, Sana Batool, Kimon Argyropoulos, Nicole Williams, Roksana Azard, and Prabodhika Mallikaratchy* “Integrating Ligand-receptor Interactions and In Vitro Evolution for Streamlined Discovery of Artificial Nucleic Acid Ligands” Mol Ther Nucleic Acids. 2019 Sep 6;17:150-163. doi: 10.1016/j.omtn.2019.05.015. Epub 2019 Jun 4.

The role of G-quadruplex structures of LIGS-generated aptamers R1. 2 and R1. 3 in IgM specific recognition

Federica Moccia,Chiara Platella, Domenica Musumeci, Sana Batool, , Hasan Zumrut, John Bradshaw, Prabodhika Mallikaratchy*, Daniela Montesarchio* “The role of G-quadruplex structures of LIGS-generated aptamers R1. 2 and R1. 3 in IgM specific recognition” : Int J Biol Macromol. 2019 Apr 22; 133:839-849. doi:10.1016/j.ijbiomac.2019.04.141; 2019.

Ligand-guided-selection method for screening antigen-specific ligands

US Patent application: 10/253,314, “Ligand-guided-selection method for screening antigen-specific ligands”

Synthesis of stable azide and alkyne functionalized phosphoramidite nucleosides

S Lingala, LU Nordstrøm, PR Mallikaratchy “Synthesis of stable azide and alkyne functionalized phosphoramidite nucleosides”: Tetrahedron Letters, 2019 January 17; 60(3):211-213. doi:10.1016/j.tetlet.2018.12.018

Dimerization of an aptamer generated from Ligand-guided selection (LIGS) yields a high affinity scaffold against B-cells

Sana Batool, Kimon V Argyropoulos, Roksana Azad, Precious Okeoma, Hasan Zumrut, Sanam Bhandari, Rigzin Dekhang, Prabodhika Mallikaratchy* ” Dimerization of an aptamer generated from Ligand-guided selection (LIGS) yields a high affinity scaffold against B-cells “Biochimica et Biophysica Acta (BBA)-General Subjects 1863 (1), 232-240. doi:10.1016/j.bbagen.2018.10.006. Epub 2018 Oct 17.

Conformational behaviour and molecularity of novel anti-IgM G-quadruplex forming aptamers

Federica Moccia, Domenica Musumeci, Chiara Platella, John Bradshaw, Prabodhika Mallikaratchy, Daniela Montesarchio. “Conformational behaviour and molecularity of novel anti-IgM G-quadruplex forming aptamers” 2018 August 19; 256th ACS National Meeting

Ligand-guided selection (LIGS): A SELEX variant to identify specific aptamers against cell-surface markers

Hasan Zumrut, Sana Batool, Kimon Argyropoulos, Rigzin Dekhang, Prabodhika Mallikaratchy. “Ligand-guided selection (LIGS): A SELEX variant to identify specific aptamers against cell-surface markers” 2018 August 19. 256th ACS National Meeting.

Design of a dimeric aptamer against B-cell receptor

Sana Batool, Hasan Ekrem Zumrut, Sanam Bhandari, Nabeela Van, Shanell George, Prabodhika Mallikaratchy. “Design of a dimeric aptamer against B-cell receptor” 2018 March 18. 255th ACS National Meeting.

Engineered Aptamers to Probe Molecular Interactions on the Cell Surface

Sana Batool, Sanam Bhandari, Shanell George, Precious Okeoma, Nabeela Van, Hazan E. Zümrüt, and Prabodhika Mallikaratchy “Engineered Aptamers to Probe Molecular Interactions on the Cell Surface” Biomedicines. 2017 Aug 29;5(3). pii: E54. doi:10.3390/biomedicines5030054.

Structural optimization of an aptamer generated from Ligand guided Selection (LIGS) resulted in high affinity variant toward mIgM expressed on Burkitt’s lymphoma cell lines: Biochimica et Biophysica Acta (BBA)-General Subjects

Hazan E. Zümrüt, Sana Batool, Nabeela Van, Shanell George, Sanam Bhandari and Prabodhika Mallikaratchy Structural optimization of an aptamer generated from Ligand guided Selection (LIGS) resulted in high affinity variant toward mIgM expressed on Burkitt’s lymphoma cell lines: Biochimica et Biophysica Acta (BBA)-General Subjects.2017 July 01; 1861(7):1825-1832. pii: S0304-4165(17)30111-3. doi:10.1016/j.bbagen.2017.03.020.