Prabodhika Mallikaratchy, PhD
Associate Professor Department of Chemistry
City University of New York — Lehman College
PhD Program in Chemistry
PhD Program in Biochemistry
PhD Program in Molecular Cellular and Developmental Biology
The Graduate Center of the City University of New York, New York
Grad. I. Chem C., Institute of Chemistry, Sri Lanka.
M.S. University of Louisiana at Monroe.
Ph.D. University of Florida.
Postdoctoral fellow, Memorial Sloan Kettering Cancer Center.
Long-term goal of this laboratory is to develop oligonucleotide aptamer based synthetic antibodies for biological and biomedical applications. Therefore, this research program is aimed at generating new aptamers against biologically important cellular targets, and molecular engineering of multifunctional aptamer structures suitable for drug delivery.
Nucleic acid aptamers (nucleic acid based antibody analogues) are short DNA/RNA sequences, which specifically bind to a target molecule with high affinity and/or specificity. The method of selecting aptamers is called systematic evolution of ligands by exponential enrichment (SELEX).
Our laboratory is focused on two major areas of aptamer research:
- Investigation of novel SELEX technologies to select aptamers against biologically important cellular targets.
- Design and synthesis of novel multivalent, multifunctional aptamer scaffolds for biomedical applications. We are also interested in structure-activity relationship studies of monomeric and multimeric aptamers.